MATERNAL OUTCOME IN ADVANCED MATERNAL AGE (>35Yrs) - A PROSPECTIVE CASE CONTROL STUDY
DOI:
https://doi.org/10.66328/ijprmh.2025.010102Keywords:
Pregnancy in Later Life, Pregnancy Outcome, Maternal Age, Gestational Diabetes, Hypertension, Pregnancy-InducedAbstract
Background: Advanced maternal age (AMA), defined as pregnancy at ≥35 years, is increasingly prevalent and has been associated with adverse maternal and perinatal outcomes. This study aimed to evaluate maternal outcomes in AMA women compared with younger mothers.
Methods: A prospective case–control study was conducted in the Department of Obstetrics and Gynaecology, Kalpana Chawla Government Medical College, Karnal, over 18 months. A total of 80 antenatal women beyond 28 weeks of gestation were enrolled and divided into two groups: Group I (n=40, ≥35 years) and Group II (n=40, 20–34 years). Maternal outcomes assessed included hypertensive disorders, gestational diabetes mellitus (GDM), antepartum haemorrhage, preterm premature rupture of membranes (PPROM), and mode of delivery. Statistical analysis was performed using SPSS v25, with p<0.05 considered significant.
Results: Women in the AMA group were significantly older (mean 37.6 vs. 26.0 years, p<0.001) and predominantly multiparous (82.5% vs. 30.0%, p<0.001). Overweight and obesity were more frequent among AMA women, though not statistically significant. The frequency of maternal complications was higher in the AMA group, with GDM (22.5% vs. 7.5%) and hypertensive disorders (17.5% vs. 5.0%) showing a notable trend, though differences were not statistically significant. Preterm labour (20% vs. 22.5%) and PPROM (10% vs. 7.5%) were comparable. Mean gestational age at delivery was similar in both groups (37.2 vs. 37.3 weeks).
Conclusion: AMA is associated with increased risks of GDM, hypertensive disorders, and preterm complications, underscoring the importance of targeted antenatal surveillance and individualized care strategies for optimizing maternal outcomes.
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